Technical Topics → Specialty Specific → Toxicology

Ion Suppression in LCMS Methods: Detect and Correct


Description
Presented by: Gillian Terracina

Objectives:
● Define ion suppression and matrix effects
● Understand why ion suppression should be investigated as part of the method validation
● Understand the methods used to detect ion suppression
● Know what is a suitable internal standard
● Become familiar with how an internal standard is used to correct for matrix effects
● Know what to look for when reviewing validation studies for matrix effects
● Become aware of other types of ion suppression (it's not always the matrix)
Content
  • Recording of Presentation [0:31:07]
  • Powerpoint Slides
  • related documents
  • Ion Suppression Example
Completion rules
  • All units must be completed